Terms & Conditions of Use

Nirogy Therapeutics (“Nirogy”) is pleased to provide you with materials on our website for informational purposes.  PLEASE READ THESE TERMS AND CONDITIONS OF USE CAREFULLY.  BY USING THIS WEBSITE, YOU INDICATE YOUR ACCEPTANCE OF THESE TERMS AND CONDITIONS.  IF YOU ARE VIEWING THIS ON YOUR MOBILE DEVICE, YOU CAN ALSO VIEW THESE TERMS VIA A WEB BROWSER AT nirogytx.com.   If you do not accept these terms and conditions, you should exit the website now. 

We may revise the terms discussed here at any time without notice by updating this posting. You are bound by any revisions and, therefore, should periodically visit this page to review the current terms that apply to your use of our website.

Access to the Website: When using our website, your telecommunications carrier’s normal rates and charges apply. We are not responsible for any charges you incur from your telecommunications carrier as a result of use of our Services.  You are responsible for ensuring that, at all times while using our Services, you are not in violation of your agreement with your telecommunications carrier.

Nirogy maintains this website from our offices in Natick, Massachusetts. This website is intended to be accessed from, and the information contained in the website is intended to be used within, the United States of America. We make no representations that this website or materials in our website are appropriate or available for access or use in other countries. If you access this website from another country, you do so on your own initiative and are responsible for compliance with laws applicable to such access.

Copyright and Trademark Information: This website, and the information which it contains, is the property of Nirogy and its affiliates and licensors, and is protected from unauthorized copying and dissemination by United States copyright law, trademark law, international conventions and other intellectual property laws. By way of example only, and not as a limitation, “Nirogy” and “Nirogy Therapeutics” are registered trademarks under the applicable laws of the United States.

All registered and unregistered trademarks, including product names, are property of their respective owners.

Use Of Nirogy Website And Its Content: Subject to these Terms and any other agreement between you and us, we grant you a limited, personal, nonexclusive, nontransferable, non-sublicensable, revocable license to use our website solely in the manner enabled by us and for your personal, non-commercial purposes.  Your license to use our website is automatically revoked if you violate these Terms.  From time to time, we may upgrade our website or make improvements to our website. You agree that these Terms will apply to any such upgrades or improvements.  The foregoing license grant is not a sale of any portion of our website or its content, and we and our partners and suppliers retain all rights and interest in our website. Any attempt by you to transfer any of the rights, duties or obligations hereunder, except as expressly provided for in these Terms, is void. We reserve all rights not expressly granted under these Terms. 

The information contained in this website is for general guidance on topics selected by Nirogy. The application and impact of relevant laws will vary from jurisdiction to jurisdiction. The information on this website may contain inaccuracies, omissions or typographical errors. Nirogy expressly disclaims any obligation or duty to update or correct information contained in this website.  The information on this web site is provided with the understanding that Nirogy and various authors and publishers’ providing such information does not constitute the rendering of legal, accounting, tax, career or other professional advice or services. As such, information on this website should not be relied upon or used as a substitute for consultation with professional advisors.

Nirogy may alter, suspend or discontinue this website at any time for any reason, without notice. The website may become unavailable due to maintenance or malfunction of computer equipment or other reasons. Nirogy reserves the right to make changes to document names and content, specifications, or other information on the web site without obligation to notify any person of such changes.  In order to use our website, you must have a computer with Internet access that can access our website or a compatible mobile device enabled with a browser. No part of this website may be reproduced or transmitted in any form, by any means, electronic or mechanical, including photocopying and recording, or used to create derivative works, except that Nirogy authorizes you to view, copy, download, and print Nirogy documents (such as white papers, press releases, data sheets, and FAQs) that are available on this website, subject to the following conditions:

  • The documents may be used solely for noncommercial, informational purposes.
  • The documents may not be modified.
  • Copyright, trademark, and other proprietary notices may not be removed.

Nothing contained on this website should be construed as granting, by implication, estoppel, or otherwise, any license or right to use this web site or any documents displayed on this web site, through the use of framing or otherwise, except: (a) as expressly permitted by these terms and conditions; or (b) with the prior written permission of Nirogy or such third party that may own the trademark or copyright of material displayed on this website.

Medical Information: This website may contain general information relating to various medical conditions and their treatment. Such information is provided for informational purposes only and is not meant to be a substitute for advice provided by a doctor or other qualified healthcare professional. Nirogy is not engaged in rendering medical or similar professional services or advice via this web site, and the information provided is not intended to replace medical advice offered by a physician. You should not use the information contained herein for diagnosing a health or fitness problem or disease. You should always consult with a doctor or other healthcare professional.

Privacy: All information that you provide through our website is subject to our Privacy Policy, as may be in effect from time to time. You are responsible for keeping your registration information up to date through your account page, to the extent such feature is made available through our website.

Our Privacy Policy describes the collection, use and disclosure of data and information by us in connection with our website.  The Privacy Policy, as may be updated by us from time to time in accordance with its terms, is hereby incorporated into these Terms, and you agree to the collection, use and disclosure practices set forth therein.

By using our website, you consent to receiving communications from us as further described in the Privacy Policy. Please read the Privacy Policy to learn more about your choices regarding our electronic communications practices. You agree that any notices, agreements, disclosures or other communications that we send to you electronically will satisfy any legal communication requirements, including written communications.

No Warranties: Information and documents, including specification, provided on this website are provided “as is.”  Specifically, but without limitation, Nirogy does not warrant that: (i) the information on this website is correct, accurate, reliable or complete, (ii) the functions contained on this website will be uninterrupted or error-free; (iii) defects will be corrected, or (iv) this website or the server(s) that makes it available are free of viruses or other harmful components.

Descriptions and specifications are subject to change. Nirogy periodically adds or updates the information and documents on this web site without notice.

It is the user’s responsibility to ascertain whether any information downloaded from this web site is free of viruses, worms, Trojan horses, or other items of a potentially destructive nature.

Disclaimer; Limitation Of Liability: It is your responsibility to evaluate the accuracy, completeness or usefulness of any information, opinion, advice or other content available through our website.

OUR WEBSITE AND ALL CONTENT ON OR ACCESSIBLE FROM OUR WEBSITE IS PROVIDED “AS IS” WITHOUT WARRANTY OF ANY KIND, EITHER EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION THE IMPLIED WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NON-INFRINGEMENT. SPECIFICALLY, BUT WITHOUT LIMITATION, WE DO NOT WARRANT THAT: (i) THE INFORMATION AVAILABLE THROUGH OUR WEBSITE IS FREE OF ERRORS; (ii) THE FUNCTIONS OR SERVICES (INCLUDING WITHOUT LIMITATION MECHANISMS FOR DOWNLOADING AND TRANSMITTING CONTENT) PROVIDED BY OUR WEBSITE WILL BE UNINTERRUPTED, SECURE OR FREE OF ERRORS; (iii) DEFECTS WILL BE CORRECTED, OR (iv) THAT OUR SERVERS OR THE SERVER(S) THAT MAKE THEM AVAILABLE ARE FREE OF VIRUSES OR OTHER HARMFUL COMPONENTS.

WE AND OUR AFFILIATES AND LICENSORS CANNOT AND DO NOT GUARANTEE THAT ANY PERSONAL INFORMATION SUPPLIED BY YOU WILL NOT BE MISAPPROPRIATED, INTERCEPTED, DELETED, DESTROYED OR USED BY OTHERS.

IN NO EVENT SHALL WE BE LIABLE TO YOU, ANY OTHER USER OF OUR WEBSITE,  ANY THIRD PARTY PROVIDERS OR ANY OTHER PERSON OR ENTITY FOR ANY SPECIAL, INCIDENTAL, PUNITIVE, CONSEQUENTIAL, EXEMPLARY OR OTHER INDIRECT DAMAGES (INCLUDING WITHOUT LIMITATION DAMAGES FOR LOSS OF PROFITS, LOSS OF DATA, LOSS OF USE OR COSTS OF OBTAINING SUBSTITUTE GOODS OR SERVICES) ARISING OUT OF THE USE, INABILITY TO USE, UNAUTHORIZED ACCESS TO OR USE OR MISUSE OF OUR WEBSITE, YOUR CONTACT INFORMATION, CONTENT OR ANY INFORMATION CONTAINED THEREON, WHETHER BASED UPON WARRANTY, CONTRACT, TORT (INCLUDING NEGLIGENCE), OR OTHERWISE, EVEN IF WE HAVE BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGES OR LOSSES. 

SOME JURISDICTIONS DO NOT ALLOW THE EXCLUSION OF CERTAIN WARRANTIES OR THE LIMITATION OR EXCLUSION OF LIABILITY FOR INCIDENTAL OR CONSEQUENTIAL DAMAGES.  ACCORDINGLY, SOME OF THE ABOVE LIMITATIONS MAY NOT APPLY TO YOU BUT SHALL INSTEAD APPLY TO THE MAXIMUM EXTENT PERMITTED BY LAW.

Third Party Links: This web site may contain links to non-Nirogy websites. These links are provided to you as a convenience, and Nirogy is not responsible for the content of any linked web site. We may integrate our website so that you can record or share your use of our website through a third party social networking service.  Any outside website accessed from or social media platform integrated with the Nirogy website is independent from Nirogy, and Nirogy has no control over the content or accuracy of that website or service. In addition, a link to any non-Nirogy website or service does not imply that Nirogy endorses or accepts any responsibility for the content or use of such a website or service.

No Implied Endorsements: In no event shall any reference to any third party or third party product or service be construed as an approval or endorsement by Nirogy of that third party or of any product or service provided by a third party, including the opinions or predictions of financial analysts regarding Nirogy or its securities.

Submissions To Nirogy And Affiliated Servers: Any information, including but not limited to remarks, suggestions, ideas, graphics, or other submissions, communicated to Nirogy through this website is the exclusive property of Nirogy. Nirogy is entitled to use any information submitted for any purpose, subject to the Privacy Policy, and without compensation to the person making the submission.

If you submit material to be made available to other users through our website (“Content”), you hereby grant us a non-exclusive, perpetual, irrevocable, worldwide, sublicensable, transferable, royalty free, fully paid up license to reproduce, distribute, prepare derivative works of, modify, translate, adapt, publicly perform, publicly display and otherwise use any such Content that you submit to us, and you understand that we may allow any third party to use such Content. You acknowledge the originality of any Content submitted to Nirogy and accept responsibility for its accuracy, appropriateness, and legality.  We may remove, modify or alter such Content at any time, without obligation to issue any notice of such changes.

Nothing contained on our Services should be construed as granting, by implication, estoppel, or otherwise, any license or right to use our website or any Content, through the use of framing or otherwise, except: (a) as expressly permitted by these Terms; or (b) with our prior written permission or the permission of the third party that may own the trademark or copyright of material displayed on the website.

You agree that by submitting content:

  • that, if you are a healthcare professional, you will not submit any information that would directly identify a patient or any information for which you do not have all necessary consents or authorizations to disclose;
  • you will only submit content that complies with applicable law, and will not submit Content that is abusive, defamatory, obscene, infringing, fraudulent, threatening, repetitive, or otherwise inappropriate, or that contains any viruses or other software that may adversely affect the operation of another’s computer; and
  • Nirogy is free, without payment of compensation to you, to use any ideas, concepts, know-how or techniques contained in any communication or material you send to our website for any purpose whatsoever.
  • You agree not, and will not permit any person or entity, to: (i) use, or allow the use of, the website for any unfair or deceptive practices or in contravention of any federal, state, local, foreign, or other applicable law, or rules and regulations of regulatory or administrative organizations; (ii) act in a fraudulent, tortious, malicious, or negligent manner when using our website; (iii) obtain unauthorized access to any computer system through our website; (iv) circumvent, remove or otherwise interfere with any security-related features of our website, features that prevent copying or using any part of our website or features that enforce limitations on the use of our website or any Content; (v) introduce viruses, worms, Trojan horses and/or harmful code to our website or the systems that operate our website; or (vi) use any robot, spider, site search/retrieval application, or other automated device, process, or means to access, retrieve, scrape, or index any portion of our website or any Content.

We reserve the right to consider other conduct to be prohibited; the restrictions above are intended to be illustrative.

Copyright Infringement; DMCA Policy: If you believe that any materials on our website infringe your copyright, you may request that such materials be removed by contacting us at: ir@Nirogytx.com.  This request must bear a signature (or electronic equivalent) of the copyright holder or an authorized representative and must include the following information:  (1) identification of the copyrighted work that you believe to be infringed, including a description of the work and, where possible, a copy or the location of an authorized version of the work; (2) identification of the material that you believe to be infringing and its location, including a description of the material, its location on our website or other pertinent information that will help us to locate the material; (3) your name, address, telephone number and email address; (4) a statement that you have a good faith belief that the complained of use of the materials is not authorized by the copyright owner, its agent or the law; (5) a statement that the information in your claim is accurate; and (6) a statement that “under penalty of perjury,” you declare that you are the lawful copyright owner or are authorized to act on the owner’s behalf.

Miscellaneous: These Terms and Conditions are governed and interpreted pursuant to the laws of Delaware, United States of America, notwithstanding any principles of conflicts of law that would dictate the application of the law of another jurisdiction.

If any part of these terms is unlawful, void, or unenforceable, that part will be deemed severable and will not affect the validity and enforceability of the remaining provisions. Nirogy may, at its sole discretion and without notice, revise these terms at any time by updating this posting.

You may not assign or transfer your rights or obligations under these Terms in whole or in part to any third party without our consent.  These Terms shall bind and inure to the benefit of the parties to these Terms and their respective successors, permitted transferees and permitted assigns.  We and you are independent contractors and are not partners, joint venturers, agents, employees or representatives of the other party.  The headings and captions used in these Terms are used for convenience only and are not to be considered in construing or interpreting these Terms.  If any part of these Terms is held to be unlawful, void, or unenforceable, that part will be deemed severable and shall not affect the validity and enforceability of the remaining provisions.  This is the entire Agreement between the parties relating to the subject matter herein and shall not be modified except in writing signed by both parties or by a new posting by Nirogy, as described above.

If you have any questions about the rights and restrictions above, please contact us at info@Nirogytx.com.  
Effective Date:   December 23, 2020
Copyright © 2020, Nirogy Therapeutics. All Rights Reserved.

Lactate Transporters

Monocarboxylate Transporters (MCTs) are a subfamily of SLCTs consisting of 14 metabolite transporters. Of those, MCT1 and MCT4 are key isoforms that transport Lactate metabolite “in and out” of cells in a bidirectional fashion.

One-hundred years ago, Otto Warburg first observed that tumors utilize unusually high amounts of glucose (blood sugar) as the food source and produce lactic acid compared to normal cells in the body without using ample oxygen available for energy production – the phenomenon termed as the “Warburg effect”. This effect results from metabolic reprogramming during oncogenic transformation in cancer to generate the building blocks required for continuous cell proliferation and rapid growth relative to normal cells. Lactate metabolite is formed as a strong acid from glycolysis within the cell and is exported out of the cell through MCT1 and MCT4 to prevent its buildup inside the cell, which is detrimental to cancer cell survival. On the other hand, the exported lactate accumulates and acidifies the extracellular space in the tumor microenvironment (TME), creating a hostile environment for immune cells to survive and thereby making our body’s natural immune system unable to attack the tumor.

Nirogy has discovered a series of small molecule dual inhibitors that bind to both MCT1 and MCT4 (dMCTi), which can block lactate export, thus directly killing cancer cells and simultaneously restoring the immune function by lowering the acidity in the TME.

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Vincent P. Sandanayaka, Ph.D.

FOUNDER

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